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HEAVYMETHYL Report Summary

Project ID: 309384
Funded under: FP7-IDEAS-ERC
Country: Netherlands

Mid-Term Report Summary - HEAVYMETHYL (Regulation of gene expression and cell fate by DNA (hydroxy)methylation)

During embryonic development, the expression of many genes in different tissues is switched on or off, which results in the generation of many differentiated cell types, which all carry the same genome sequence. (Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on gene expression patterns and phenotype, but are inherited from mother to daughter cells independent of the underlying DNA sequence. In the project ‘HeavyMethyl’, state-of-the-art proteomic and genomic approaches are being used to investigate the biological function of DNA (hydroxy)methylation and the proteins that interact with these epigenetic modificiations during embryonic stem cell differentiation.

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