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BeadsOnString Report Summary

Project ID: 337830
Funded under: FP7-IDEAS-ERC
Country: Israel

Mid-Term Report Summary - BEADSONSTRING (Beads on String Genomics: Experimental Toolbox for Unmasking Genetic / Epigenetic Variation in Genomic DNA and Chromatin)

The Beads-on-string projects aims to develop a toolbox for genomic analysis of individual DNA molecules. During the first period of the project the team has developed a novel method, CATCH, to target specific genomic regions and excise them from the genome for further analysis. Our goal is to visualize genetic and epigenetic patterns on such genomic fragments. This is done by attaching fluorescent markers to the DNA at specific locations followed by stretching the labeled DNA in nanochannel arrays for imaging. We have developed a method for fluorescent labelling of the epigenetic mark 5hmC and demonstrated for the first time a combined genetic and epigenetic profile of individual genomic DNA molecules.

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