Community Research and Development Information Service - CORDIS



Project ID: 337637
Funded under: FP7-IDEAS-ERC
Country: Israel

Mid-Term Report Summary - OPTONEUROMOD (Optical dissection of prefrontal neuromodulation: from synapses through networks to behavior)

OPTONEUROMOD is a project aimed at developing and utilizing advanced optical techniques for understanding how specific brain systems interact to guide complex behavioral processes such as attention, memory and emotion. Using cutting-edge optical and genetic engineering techniques, the team in Dr. Yizhar's laboratory is developing technologies for controlling the activity of defined brain pathways in order to assign these pathways with specific roles in the complex network of the brain. The team uses optogenetic techniques, which utilize light for modifying the activity of neurons, in order to examine the circuits of the frontal cortex and the limbic system which together interact to regulate cognitive and emotional processes. Achieving a better understanding of how these systems operate in the healthy brain will also shed light on the mechanisms by which they are impaired in psychiatric and neurodevelopmental disease.

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