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Artificial Mitochondria for Health

Final Report Summary - MITOCHON (Artificial Mitochondria for Health)

mitochon quested to build a biomimetic system able to produce the chemical energy in form of ATP inside eukaryotic cells. To achieve this goal we have been working on three parallel research lines: the collection of the biological building blocks, the targeting and internalization of the biomimetic system into cultured cells and the release and tracking of the newly synthesized ATP inside the cell. We have been able to successfully assemble the minimal components into an artificial system able to in situ produce ATP, promote its vehiculization into targeted cells and accurately monitor the increased energetic levels within living cells. We deliver as a proof of concept a first functional prototype that will lead to the fabrication of long lifetime artificial mitochondria.