Community Research and Development Information Service - CORDIS


CAD-BONE — Result In Brief

Project ID: 286179
Funded under: FP7-PEOPLE
Country: Spain
Domain: Health, Information and communication technology

Computer models predict bone treatment outcome

Bone remodelling is a complex biological process that involves the interaction of many cell types and factors. A computer model of this process could predict the long term responses following surgical intervention.
Computer models predict bone treatment outcome
Many musculoskeletal diseases necessitate the use of artificial prosthetic implants. However, accumulating evidence indicates that the functional outcome of such treatments is patient-dependent, requiring a deeper understanding of the factors that drive bone adaptation to the implant.

The scope of the EU-funded CAD-BONE (Patient-specific predictions for bone treatments) project was to develop technology capable of simulating bone adaptation/healing after prosthesis implantation. For this purpose, researchers combined image processing, musculoskeletal modelling and bone remodelling algorithms under one tool. The idea was to predict bone morphological changes resulting from alterations in mechanical loading conditions.

Researchers generated a specific model of the femur, where the muscle attachment regions and forces were identified by gait analysis. Using this model, they were able to predict bone density distribution similarly to standard CT images. Different phenomenological-based bone remodelling models were tested alongside models that simulated the healing of complex bone fractures. These models were validated in clinical cases of a known outcome. Furthermore, the consortium employed different numerical analyses to accelerate bone remodelling simulations.

Taken together, the CAD-BONE activities and technological advances provided novel methodology for predicting the outcome of prosthetic treatment. The improved knowledge of the mechanical factors that influence bone remodelling and healing is of paramount importance for the design of effective therapies.

Related information


Computer model, bone, prosthetic implant, CAD-BONE, healing, bone remodelling
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