Community Research and Development Information Service - CORDIS



Project ID: 612224
Funded under: FP7-PEOPLE
Country: Italy

Periodic Report Summary 1 - EVESTEMINJURY (Extracellular Vesicles and exosomes from adult stem cells in the regeneration of organ injury)

The EVEStemInjury project aims to explore the different necessary aspects in order to get a deeper knowledge on EVs, on their mechanisms of action in tissue injury, on the relevance of their content, specifically miRNAs and the mRNA, healing patterns in stem cells from different sources in the mediation of the biologic effect of EV. In order to achieve the overall objectives of the project, the following four technical WPs have been defined:
WP1: Definition of biological ingredients;
WP2: Mechanisms of actions;
WP3: EV production strategies;
WP4: Renoprotective and regenerative effects assessment.
The work started as planned. Model systems have been set for the activities in the 4 WPs and good progress was made on the identification of specific healing patterns that mediate the EVs protection and tissue regeneration activity. Moreover the delivery efficiency of natural and synthetic EVs was exploited.So far one third of the secondments have been completed. Each WP has different ways of transfer of knowledge and the true synergies in this project arise from combining researchers from completely different field of expertise under one common working programme. Within each of these exchanges, in the one hand the hosting site had the chance to benefit from the expertise of the seconded researcher, while the seconded researcher took the opportunity of his/her stay to be trained on innovative techniques/ or increase it knowledge in some specific areas, which will be interesting for its career development.
More specifically participating researchers received some specific training related to EV characterization and drug delivery system, and lectures on Communication in science and Project management (WP5).
Dissemination activities (WP6) were organized by the partners to increase the awareness of Marie Curie grants opportunities and the general public understanding of the researched field. They include a peer reviewed publication and poster presentations at international meetings, as well as presentations and events directed to the general public, such as dissemination at National Science Day (UMCU), at the London International Youth Forum (LMU) or the exposure of EVESteminjury Information poster at the hospital entrance (IDIBAPS).
Management activities were performend as planned under WP7.
More information can be found at the project website:

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Life Sciences
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