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ADOS Report Summary

Project ID: 339541
Funded under: FP7-IDEAS-ERC
Country: France

Mid-Term Report Summary - ADOS (AMPA Receptor Dynamic Organization and Synaptic transmission in health and disease)

AMPA glutamate receptors (AMPAR) play key roles in information processing by the brain as they mediate nearly all fast excitatory synaptic transmission. Their spatio-temporal organization in the post synapse with respect to presynaptic glutamate release sites is a key determinant in synaptic transmission. The activity-dependent regulation of AMPAR organization is at the heart of synaptic plasticity processes underlying learning and memory. Dysfunction of synaptic transmission - hence AMPAR organization - is likely at the origin of a number of brain diseases.
We are developing innovative imaging methods and molecular tools to visualize and perturb AMPA receptor organization and function at an unprecedented resolution. We have identified new AMPA receptor auxiliary proteins. We have identified new processes that link AMPA receptor trafficking to activity dependent modifications of synaptic transmission. We apply these findings to understand the causes of early cognitive deficits in models of neurodegenerative disorders and open new avenues of research for innovative therapies.

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