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LipoCheX Report Summary

Project ID: 340896
Funded under: FP7-IDEAS-ERC
Country: Austria

Mid-Term Report Summary - LIPOCHEX (The Role of Lipolysis in the Pathogenesis of Cancer-associated Cachexia)

LipoCheX investigates the role of triglyceride (TG) catabolism (lipolysis) in the pathogenesis of cancer and cancer-associated cachexia (CAC). Our research revealed novel mechanisms how lipolysis affects cancer and CAC in mice. For example, we discovered a metabolic axis where CAC induces lipolysis and browning of white adipose tissue contributing to increased energy consumption and wasting. In search of potential treatment strategies, we developed pharmacological inhibitors of lipolysis and found that Atglistatin, an inhibitor of the rate-limiting enzyme of TG degradation, prevents high-fat diet induced obesity, insulin resistance and hepatosteatosis in mice. We expect that LipoCheX will continue to provide new mechanistic insights into the link between lipid metabolism and cancer/CAC and offer novel approaches to treat metabolic diseases such as CAC.

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