Community Research and Development Information Service - CORDIS

Periodic Report Summary 1 - ABC (Harnessing Carboxylic Acids via ABC – Asymmetric Boronic acid-based Catalysis)

The main objective of this Marie Curie Career Integration Grant project was the development of new chemical methodologies for the functionalization of organic molecules without the aid of any transition metals. One of the main aspects of the project was to overcome the low reactivity of carboxylic acids and amines.
Given the relevance of organic molecules in every aspects of our daily life, this relevance and impact of this project would be demonstrated with the total synthesis and late-stage modification of molecules with biological, therapeutic and agrochemical properties.
Since the beginning of the Award, we have developed novel chemical reactions of carboxylic acid derivatives with the aid of abundant and benign Calcium-based catalysts.
More recently, we have started a program aimed at using visible-light for the easy synthesis of nitrogen-containing compounds like amines, imines and amides. Specifically, we have developed a powerful transition metal-free approach for the generation of nitrogen radicals. These odd-electron species have great potential in the synthesis of molecules that directly impact many aspects of our daily life (e.g. therapeutic agents, agrochemicals, food additives).
The results supported but the Award have resulted in four publications in high quality international journals and they have been presented at several international conferences around the world (Korea, Spain, Germany, UK). The impact of the research supported by the Career Integration Grant has been recognised by the award of two international Early Career Prizes to the applicant.

Reported by

United Kingdom


Life Sciences
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