Community Research and Development Information Service - CORDIS

Periodic Report Summary 1 - PASCAL (Pax8 as a marker of Ovarian cancer Originating in the Fallopian tube)

Ovarian cancer is the deadliest gynecological malignancy in the western world. In recent years we and others have established that a large proportion of high grade serous carcinomas (HGSC), the most common subtype of ovarian cancer, arises in the fallopian tube. This understanding has highlighted the role of the fallopian tube lineage marker, the transcription factor PAX8. PAX8 is expressed in the fallopian tube secretory epithelial cell (FTSEC), the proposed cell-of-origin of HGSC, and, as we have shown, in nearly 100% of HGSC. The center of this proposal is studying the role of PAX8 in normal FTSEC and in HGSC. During the time period of this proposal, our research revealed the central and essential role of PAX8 in HGSC, but not in FTSEC, and has made inroads into the targets of PAX8 that mediate this role.
The work described in this proposal is the corner stone of the work done in the Perets lab in the last two years. Since the acceptance of this grant our lab has grown significantly. We now have 3 graduate students, two undergraduate students, and a research associate performing research in the lab. Our current findings lay the foundation for our research in the coming years, and allowed a steady flow of new grant received in the lab. I expect that our results that are currently being prepared for publication would be of high interest to the ovarian cancer research community and in due time will allow for discovery of novel ovarian cancer therapeutics.

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Life Sciences
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