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Naturale CG Report Summary

Project ID: 616417
Funded under: FP7-IDEAS-ERC
Country: United Kingdom

Mid-Term Report Summary - NATURALE CG (Engineering Bio-inspired Materials for Biosensing and Regenerative Medicine)

Naturale CG has progressed extremely well since starting in July 2014. The progress of this grant is on track and has seen no significant deviations. Many of the objectives have been met and seen excellent and high impact outcomes thus far. We have published over 20 papers in journals such as Nature Materials, Cell Stem Cell, ACS journals and elsewhere.

We reported the co-development of innovative “nanoneedles” capable of rapid, efficient and safe delivery of biomolecules, delivery of quantum dots and mapping tumorous margins in Nature Materials, ACS Nano and Advanced Materials in 2015. This nanotechnology is a platform technology with enormous potential that we continue to exploit for their unique integration capabilities with cells and tissues. In 2015 we reported a device capable of detecting phospholipase A2, a biomarker for acute pancreatitis, in clinically relevant ranges (ACS Nano 2015). We have also continued our investigations of detecting biomarkers for HIV and developed an exciting new biosensing approach based on fluorescent detection (Chemistry of Materials 2015). We also exploited the chirality of DNA to pair with nucleobase-peptide conjugates using metal-nucleobase recognition (Angew Chem Inter Ed 2017), resulting in self-assembled nanoparticles with plasmonic chirality and improved colloidal stability. We reported a one-pot assay based on FRET outputs and capable of detecting HIV-1 protease based on specific biorecognition events (Chemistry of Materials 2015). We also exploited liposome based materials to deliver nitric oxide as a treatment option for glaucoma (Advanced Materials 2017).

Our conductive polymer-based innovations have been reported in Science Advances 2016, Chemistry of Materials 2016, Advanced Materials 2015 and Chem 2016. Notably our rationally designed conductive patch was tested in in vivo cardiac rodent models (Science Advances 2016). We have also used a bio-inspired approach to design dual-functionalised materials that mimic native vascularised tissues to function as artificial grafts (Biomaterials 2015). Furthermore we reported hydrogels based on Streptococcal collagen–like 2 (Scl2), which supported chondrogenesis of human mesenchymal stem cells and incorporated temporal degradation (Advanced Healthcare Materials 2016 and Biomaterials 2016).

Naturale CG supported our use of Raman microspectroscopy as non-invasive approach to reveal the complexity of the multizonal organization of human cartilage (ACS Central Science 2016). In ACS Nano 2016 we used nanoanalytical electron microscopy to study biomineralisation during the earliest stages of maturation of bone mineral nucleates. We are also using high end characterisation techniques to study the cell-material interface within Naturale CG.

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United Kingdom
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