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MOMAAV Report Summary

Project ID: 617432
Funded under: FP7-IDEAS-ERC
Country: France

Mid-Term Report Summary - MOMAAV (Molecular signatures and Modulation of immunity to Adeno-Associated Virus vectors)

The overall goal of the MoMAAV program is to better understand the nature of the interaction between adeno-associated virus (AAV) vectors and the immune system, and to devise new methods to modulate immunogenicity of these vectors. The work involves studies in humans in preclinical models.
In the first half of the funding period, we established the laboratory, hired key personnel, and acquired the acquired the majority of the necessary equipment to perform the work originally described in the proposal.
Human studies conducted thus far highlighted specific signatures of the interactions of the immune system with AAV vectors that are being further explored in healthy donors and in subjects exposed to AAV vectors in gene therapy clinical trials.
Strategies to modulate immune responses to AAV vectors have been identified and are being tested in animal models. Finally, novel approaches to overcome pre-existing humoral immunity to AAV are also being developed as part of the research conducted in the context of the MoMAAV project.

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