Community Research and Development Information Service - CORDIS


Vaccinesurvey Report Summary

Project ID: 645754
Funded under: H2020-EU.1.3.3.

Periodic Reporting for period 1 - Vaccinesurvey (Monitor population immunity against vaccine preventable diseases)

Reporting period: 2015-01-01 to 2016-12-31

Summary of the context and overall objectives of the project

The objective of VACCINESURVEY is to develop and validate an innovative immune assay tool to monitor the effectiveness and coverage of immunizations programs by assessing the serum reactivity of a target population against a set of vaccine antigens chosen amongst those utilized in the EPI in an African resource poor country (Burkina Faso).
The proposed technical solution is based on a protein micro-array that function as capture substrate for serum antibodies. This assay format integrates multiplex capability and powerful analytical performance that though the generation of reactivity profiles allows on one end the monitoring of the immunization status and on the other end discriminating vaccinated versus infected individuals.
The assay results will be used to generate interactive data sets for modeling changes in the age-specific risk of infection and the risk of outbreaks.
The work of the consortium aims to demonstrate the capability of a multiplex micro-array immunoassay of minimal complexity to detect and quantify serum antibodies against tetanus, diphtheria, hepatitis B, Hemophilus, meningococcus mumps, poliomyelitis rotavirus, rubella, measles and yellow fever and its suitability in field settings. In order to move from proof of concept stage to the development of a functional assay the consortium planned its activities around the following objectives: i) set system design and specification; ii) develop a unified assay protocol and format for the detection of antibodies to vaccine components; iii) validate analytical and clinical performance; iv) discriminate vaccinated versus infected individuals; v) assess population immunity in the field; vi) develop a data base to store and visualize report based and experimentally assessed population immunity; vii) facilitate technology adoption.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

The technical activities reported under the period into question were predominantly focused on the definition of optimal assay specification, its development and validation and on the design and preparation of a dedicated database. Alongside research and development objectives the project promoted mutual transfer of knowledge between academia and industry by implementing a number of staff secondments.
The beneficiaries involved in the first two years of the project have achieved most of the planned objectives with minor delays and deviations that have been addressed by adequate corrective measures.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

The proposed assay system will strengthen the current monitoring infrastructure of the vaccine preventable diseases (VPDs) surveillance and immunization programs by enabling the implementation of objective quality control procedures, the identification of clusters of susceptible individuals and mapping the risk of disease outbreaks.
The future implementation of this technology will be able to assist in making more programmatic and strategic plans and contribute towards a better use of government and donor-supported funds and the identification on areas of immunization systems that may require additional resources. At country and regional level the proposed assay system would be instrumental for implementing objective quality control procedures, identifying clusters of susceptible individuals and mapping the risk of disease outbreaks. Therefore, the availability of an affordable, reliable and easy-to-use tool that could measure the antibody response to several vaccines, as the Vaccinesurvey consortium propose, could significantly help in both monitoring immunization programs and implementing tailored strategic decisions.
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