Community Research and Development Information Service - CORDIS



Project ID: 637860
Funded under: H2020-EU.1.1.

Periodic Reporting for period 1 - SLEEPCONTROL (The mechanism of sleep control through a sleep-active sleep-promoting neuron)

Reporting period: 2015-09-01 to 2017-02-28

Summary of the context and overall objectives of the project

Sleep is vital for animal and human life and many individuals are suffering from sleeping problems in modern societies. However, little is known about how sleep is controlled. The overall goal of this project is to understand sleep control in a model organism, Caenorhabditis elegans. Like other animals and humans, C. elegans shows sleep behavior. Sleep is controlled in both mammals and C. elegans by sleep active neurons. C. elegans uses one single sleep active neuron called RIS, which, like its mammalian counterparts, is GABAergic and peptidergic. Little is known about the control of sleep-active neurons at the molecular level in any system. C. elegans is a molecularly accessible system and solving the regulation of sleep by RIS should be feasible.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

The work in the first part has focused on functional imaging and the molecular biology of the RIS neuron.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

Novel sleep mutants and circuit mechanisms have been identified that provide insight into the control of sleep in C. elegans and that provide testable hypotheses for other systems.
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