Community Research and Development Information Service - CORDIS


Bio-Phononics Report Summary

Project ID: 340117
Funded under: FP7-IDEAS-ERC
Country: United Kingdom

Periodic Report Summary 2 - BIO-PHONONICS (Advanced Microfluidics & Diagnostics using Acoustic Holograms – Bio-Phononics)

Synopsis of Outcomes: One important aim of this application has been the development of a new understanding of the physics and engineering of the interactions between sound and liquid interfaces within phononic structures. These phononic structures can be considered analogous to "acoustic holograms" that change the nature of the wave as it passes through them, creating pressure difference in liquids which drive new and unique fluid flows. A second equally important aspect of the work has been to exploit the application of these methods in the development as a low cost diagnostic platform that are able to deliver a variety of tests, including immunoassays and DNA tests, into both the Developed and Developing worlds. This progress has been rapid and resulted in two patents being granted, a new spin out company formed with £1.8m of funding and a field trial in Uganda. We are now working with clinicians in the National Health Service in the field of diagnosis of sexually transmitted diseases within clinics.

Our concept is that different frequencies of ultrasound will interact with different phononic structures to give different functions, providing a "tool-box" of different functions (sample processing, cell separation, detection). With this, just as in electronics, where discrete components are combined to create circuits, so we are now combining different phononic lattices into a single pattern, to create fluidic microcircuits.

We are exploring a range of additional applications of this technology in blood clotting, drug delivery and disease stratification (using both mechanical and electro-mechanical separations in order to better understand the phenotype of healthy and diseased cells).

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United Kingdom
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