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ERC

UNBICAT Report Summary

Project ID: 647550
Funded under: H2020-EU.1.1.

Periodic Reporting for period 1 - UNBICAT (Unconventional Bifunctional Catalysts)

Reporting period: 2015-09-01 to 2017-02-28

Summary of the context and overall objectives of the project

The development of sustainable chemical processes is one of the most important features in modern chemistry. It has become a key research area worldwide providing solutions to important societal demands by optimizing the use of natural resources and minimizing waste and environmental impact. Among the relevant methods for achieving this goal, catalysis represents a key and central approach. Both Organocatalysis and Metal Catalysis have emerged as solutions to the problems in this context. In this field, the progress of a novel bifunctional organocatalysts that could increase the number of different activations, and therefore the synthesis of valuable enantio-enriched molecules, would be highly desirable. Especially important, but still unknown, are the bifunctional-catalysts based on a Neutral Coordinate Organocatalyst and Photo-Organocatalysts. This proposal aims to develop two new unconventional approaches for the synthesis of bifunctional organocatalysts.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

In the first 18 months, we have developed some new bifunctional Neutral Coordinate Organocatalytic system and their application to the synthesis of biologically relevant compounds. We have used these bifunctional catalysts to promote the dual activation of silyl reagents and suitable electrophiles. This approach constitutes an unconventional way to synthesize asymmetric molecules and has no precedent in the literature.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

This project has the potential to change the general view of bifunctional catalysts and photo-catalysis as we know it today. Different bifunctional catalysts based on different functions and are being synthetized in our lab and maybe incorporate into the privileged catalyst library for its applications in new asymmetric transformations for industry.
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