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ERC

TWILIGHT Report Summary

Project ID: 637801
Funded under: H2020-EU.1.1.

Periodic Reporting for period 1 - TWILIGHT (ToWards Immunisations that Last: the Immunology and Gerontology of Helper T cells)

Reporting period: 2015-06-01 to 2016-11-30

Summary of the context and overall objectives of the project

One of the major achievements of the modern era is the extension of the human life-span through improvements in medical care, nutrition, sanitation and access to clean water. The consequent shift towards older populations creates a challenge for society, not least for medical science: how to enable people to age in good health and remain active throughout their lives. Ageing is accompanied by a functional decline of the immune system, resulting in an increased overall susceptibility to infections that are a major cause of morbidity and mortality in older people. Development of strategies to mitigate or overcome these changes remains one of the major challenges of healthy ageing. One of the most successful medical interventions for preventing infectious disease has been vaccination. However, age-related changes in the immune system mean that older individuals often do not generate protective immunity after vaccination. This leads to an increased prevalence of preventable disease in older people, even with good immunisation programmes in place. Therefore, improving vaccine efficacy in older individuals is a key scientific challenge that, if met, would enable all of us to be healthier and more active throughout our lives. Most vaccines provide protection by generating antibodies that block the ability of a pathogen to establish an infection. However, antibody production after vaccination is diminished in older persons. This project aims to understand the age-dependent changes in the immune system that result in poor antibody production after vaccination.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

In Period 1 of this project we have characterised vaccine responses in younger and older individuals, and determined which changes associate with poor antibody responses.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

Improving vaccine efficacy is key to reducing infection-related morbidity in older people. To date, the complexity of the ageing process has hindered attempts to fulfil this ambition, and thus innovative approaches are required to better understand the underlying biology. This project utilises research on mice and humans to combine the tractability advantages of mice with the physiological relevance of studying humans. This will ensure that this research programme delivers mechanistic insight into a complex biological problem that is relevant to healthy ageing in humans.
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