Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS


EIMS Sintesi della relazione

Project ID: 294838
Finanziato nell'ambito di: FP7-IDEAS-ERC
Paese: Denmark

Final Report Summary - EIMS (Early infectious, inflammatory and immune mechanisms in schizophrenia)

The project has provided new solid evidence to document the role of infections and inflammation, as well as the impact of vitamin D in relation to the etiology of schizophrenia, leveraged a unique combination of Danish registers and the Neonatal Screening Biobank, and has, through substantial supplementary funding generated from other sources, also made it possible to expand into the largest study in the World, including more than 80,000 people, combing individual data on schizophrenia, bipolar disorder, depression, autism, and ADHD as well as population-based controls; documented an association between maternal infections and, for example with antibiotics use and schizophrenia; but on the other hand, we have provided solid evidence that these exposures are not mediated by inflammatory markers that could be measured in the neonatal blood spots, and the causal nature of these associations is still not established. We have also provided novel ways of combining genetic information with a wide range of environmental exposures, thereby being able to study directly the interaction between genetic liability and environmental exposures prenatally as well as during upbringing, and combine these sources with novel exposures, e.g., air quality, drinking water, and other factors.

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