Community Research and Development Information Service - CORDIS

Final Report Summary - NANOBIOMAT (Nanostructured Biocompatible/Bioactive Materials)

The aim of the Project is to design, develop, fabricate and characterize novel nanostructured bioactive materials (NSBM) for biomedical applications. The Project concept is to bring together research groups specialized in material science and experts in bio-active materials and their application in medicine. Project concept is based on combination of fundamental researches (studying interfacial phenomena and the structure-property relationships) and applied problems in the development of new bionanomaterials. The objectives of the project were based on the principle of interdisciplinary research. The main research objectives of the 4-year joint programme are: to elaborate novel drug-delivery systems based on nanoporous or nanoparticulate oxides, synthetic polymers and biopolymers; to synthesize and characterize NSBM with immobilised metal and metal oxide nanoparticles with bactericidal properties; to expand the modification of NSBM to improve their biocompatibility, to develop porous polymeric monoliths and disperse materials for pollutant and biotoxins removal from liquid media under static and dynamic regimes; to develop new NSBM based on semi-interpenetrating polymer networks (IPN) filled with metal, oxide and carbon nanoparticles for medical applications and optimize their physicochemical and mechanical properties; to elucidate the mechanisms of adsorption of bioactive compounds from aqueous solutions and biological media on NSBM; to study the structure-property relationships and a role of interfacial phenomena in performance of NSBM.
The aims of the Project were attained, the progress and achievements of the work performed in the years 2014-2017:
WP1 Drug delivery systems based on nanoporous or nanoparticulate oxides and polymers
• Synthesis and investigation of biopolymer nanogels, composites based on modified tannins for obtaining biomedical films with enhanced therapeutic activities and suitable for encapsulation of low molecular biomolecules. Controlled release of natural antioxidant Enoxil was observed (patents).
• Development of polymeric films filled with silicas modified with different functional groups and hybrid polymeric composites. Materials were developed for medical application as potential carriers of biologically active substrates.
• Synthesis of composites based on nanosilica or nanohydroxyapatite modified with synthetic polymers, natural polysaccharides.
• Synthesis and characterization of modified silicas with different structure of grafted polysiloxane layer.
• Synthesis and characterization of composites based on hydroxyapatite and carbon nanotubes.
WP2 NO-releasing nanostructured surfaces
• Development of materials with NO generation properties with good biocompatibility. Development of various techniques for NO release measurements. The obtained results suggest a potential use of the fabricated nanocomposite materials in applications for blood contacting materials.
• Preparation and characterization of nanocomposite polyvinyl chloride films with NO generating activity.
• Development of the method of fabrication of novel composite PVC/CuO and PVC/CuO/SiO2 films for generation NO release from proteins in blood environment.
WP3 Biocompatible homopolymeric and IPN-based nanocomposites filled with oxide, carbon or metal nanoparticles and biocompatibility improving additives
• Elaborating optimized procedures for obtaining promising fillers of polymer systems. Studies of structure-properties relationships and a role of interfacial phenomena in nanostructured biocompatible materials.
• Preparation and investigation of nanocomposites based on sequential semi-interpenetrating polymer network (semi-IPN) with regard to biomedical applications.
• Studies of nanocomposites based on semi-interpenetrating polymer network doped with non-functionalized multi-walled carbon nanotubes and carbochain polymer-monosaccharide hybrids.
WP4 Nanostructured materials with immobilised bactericides
• Preparation of various types of nanocomposites for biomedical applications containing ZrO2, ZrO2-Tb2O3, ZrO2-Eu2O3 nanoparticles. Studies of hybrid polyacrylamide cryogels containing modified ZrO2 nanoparticles.
• Synthesis and studies of hybrid zero-valence selenium/polymer and silver/polymer nanosystems.
• Synthesis and investigation of composites based on silica with immobilized gold nanoparticles. The complex nanoparticles have a strong antiviral effect and do not accumulate in living cells, proving non-toxicity of such antiviral nanoparticle samples. Development of composites based on silica with immobilized cerium oxide nanoparticles (patent).
• Synthesis and investigation of chitosan/silica nanofibers with silver nanoparticles and biocompatible nanocomposites based on semi-interpenetrating polymer networks and nanosilica modified by bioactive amino acid tryptophan showing antimicrobial activity.
WP5 Porous polymeric and carbon adsorbents for removal of pollutants and biotoxins
• Obtaining various types of porous microspheres with potential application as HPLC column packing materials, sorbents or organic matrices for controlled drug release.
• Synthesis and investigation of various types of materials doped with metal nanoparticles showing magnetic sensitivity, with potential application in purification systems. Obtaining the carbonaceous materials of differentiated structural and surface properties from agricultural wastes as low cost adsorbents.
• Synthesis of new composite materials by chitosan immobilization on saponite surface, organomineral materials, with regard to usage in extraction and sorption processes.
WP6 Adsorption of bio-active compounds on hydrophilic and hydrophobic surfaces
• Preparation and investigation of various types of materials showing high sorption effectiveness: amino-containing polysilsesquioxane nanoparticles, materials with magnetic properties, polymer/silica systems, porous carbons and silicas.
• Theoretical and experimental studies of adsorption (adsorption equilibria and kinetics) of bioactive molecules on various types of surfaces.
WP7 Structure-property relationships and the role of interfacial phenomena in performance of nanostructured biomaterials
• Synthesis and investigation of new materials: silica/lignin and silica/chitosan biocomposites, silica/PDMS, silica/PMPS, metal-containing composites, polymer materials. Investigation of interfacial phenomena in these systems.
• Investigation of structure-property relationships in polymer nanocomposites and surface layer of nano silica modified with polymers using different methods of particles covering.

Reported by

UNIWERSYTET MARII CURIE-SKLODOWSKIEJ
Poland

Subjects

Life Sciences
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