Community Research and Development Information Service - CORDIS

Final Report Summary - HYPOTHALAMIC T3 (The role of hypothalamic thyroid hormone in the neuroendocrine regulation of appetite, energy balance and glucose homeostasis.)

The project “Hypothalamic T3” was initiated to investigate the potential of hypothalamic thyroid hormone in the neuroendocrine regulation of appetite, energy balance and glucose homeostasis. A role for thyroid hormone in the regulation of energy expenditure has long been known with overt clinical consequences of energy imbalance in patients with thyroid dysfunction. Until recently the effects of thyroid hormone on metabolism were thought to be mediated by the action of T3 directly in peripheral tissues, but new evidence clearly points to another facet of thyroid hormone action – one of action in the hypothalamus to regulate appetite, energy balance and glucose metabolism. However, which homeostatic mechnisms thyroid hormone triggers in the brain is largely unknown. The aim of this project was to identify components of T3 action on appetite and energy balance regulatory mechanisms the hypothalamus.
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THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
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