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Final Report Summary - CHAT (Catalytic C-H activation-Initiated Tandem Reactions: Devise, Study and Application to natural renewable molecules)

On the one hand, it is now assumed that in the near future the starting materials in chemistry have to come from renewable feedstock and not only from petroleum cracking. On the other hand, the stability of the chemical bonds in saturated hydrocarbons makes them generally unreactive, and a large variety of hydrocarbons constitute a large low-cost feedstock misused, which is treated as fuel or waste. Fortunately, the recent invention of processes in which carbon–hydrogen (C–H) bonds in hydrocarbons can be activated is allowing chemists to exploit organic compounds in previously unimaginable ways. Following the principle of Green Chemistry the first issue described could be solved “C–H activating” natural renewable molecules (simple molecules obtained easily from, for example, oil from plants) and employ them as starting materials for fine chemistry.
The global objective of this project is to learn the last top advances in catalytic C–H activation and apply them to the transformation of natural renewable molecules. The specific aims of the research project are:
1) Devising C–H activation initiated tandem reactions with Rhodium catalysts and explore its application to organic synthesis. Outgoing Phase.
2)Transfer the developed methodology to the transformation of some natural renewable products– in particular Oleic Acid– into valuable molecules like drugs or drug precursors. Outgoing and Returning Phases.
3)Initiate the develoopment of new catalysts for C–H activation‐initiated tandem reactions based on group 10 metals. Outgoing Phase.

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