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Design, synthesis, structure, antitumour activity and DNA binding of new platinum compounds

An already existing collaboration in the field of platinum compounds with antitumour activity has been extended and expanded using an INTAS grant. The used platinum compounds have either the classical general formula cis-Pt(anion)2(RNH2)2, or are new-generation derivatives thereof, with different asymmetric chelating amines, or totally new dinuclear Pt complexes with a bridging amine ligand (for a review see: J. Reedijk, Improved Understanding in Platinum Antitumour Chemistry, Chem. Comm. (1996) 801-806). The design was based on our earlier experiences, and the synthesis has been primarily performed in Leiden and St Petersburg, the characterisation in Paris, Leiden and St Petersburg, the antitumour activity in Moscow and Leiden (with the assistance of the Dutch pharmaceutical company Pharmachemie) and the DNA interactions have primarily been studied in Paris, Moscow and Leiden. The co-ordinator has been collaborating with all 3 partners, whereas the other collaborations have primarily been bilateral. The INTAS grant was also meant to maintain the collaboration by allowing mutual visits, postdoctoral trainings and the purchase of chemicals and equipment the latter mainly for the partners from the FSU. This has taken place with good success and has opened doors for further and extensive collaboration. All participants are grateful to the EU and INTAS for providing the possibility.

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