Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Assessment on the effects of THz radiation on DNA bases, human lymphocytes, epithelial cell cultures and model membranes

The exploration of biological effects induced by THz radiation was aimed to provide information regarding basic data and safety issues involved in employing THz radiation in medical and technological applications. This involved the employment of different biological targets including DNA bases, model membranes (liposomes), human lymphocytes, primary human keratinocytes and a neuronal cell line.

The THz-induced biological end-points studied were alteration of membrane permeability of liposomes, induction of genotoxicity in lymphocytes as well as studying changes in cell activity, differentiation and barrier function in keratinocytes and neuronal cells. The results indicate that under various exposure conditions no biological effects could be detected. However, under some specific conditions of exposure, change in membrane permeability of liposomes was detected and an induction of genetoxicity was observed to occur in lymphocytes.

These studies suggest that medical imaging employing appropriate exposure parameters is probably unharmful at least for single exposures. Moreover, since some effects were observed to be induced by the THz radiation at a relatively low intensity when compared to the limits set by the ICNIRP for exposure, these studies should be extended to establish more accurate dose-response relationships. This is expected to provide in future improved guidelines of exposure.

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Tel Aviv University
Ramat - Aviv
69978 Tel Aviv
Israel
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