Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Development of a humanized mouse model for celiac disease

A transgenic mouse line expressing the HLA-DQ2 and a human gamma-gliadin specific T cell receptor was established. Disease-induction experiments led to the result that gluten strongly induces tolerance in the mice (not yet published). The gluten-induced tolerance can be broken by administration of high levels of interleukins or purified anti-IL10mAb.

Reported by

University of Aarhus
Brendstrupgaardsvej
8200 Aarhus C
Denmark
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