Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Distribution of all sst subtypes

With respect to the receptor subtype selective antibodies, the consortium has generated in rabbits and characterized polyclonal antibodies for rodent and human sst1, sst2A, sst2B, sst3, sst4 and sst5 antisera. With these antibodies we have established the expression pattern in more than 200 distinct areas of the rat brain for the sst subtypes. They all showed a broad overlapping expression pattern.

Only few structures were almost free of sst immunstaining, such as the Edinger-Westphal nucleus or layer I of the cerebral cortex. In general all subtypes but sst5, which we could not reliably detect in adult brain, were prominantly present in olfactory structures, suggesting roles in processing chemical sensory information. Moreover, sst1 was abundantly seen in the deep layers of cerebral cortex and granule cell layer of the cerebellum, while sst2A and sstB are probably the most ubiquitously expressed variants.

At the cellular level sst subtypes were present on neurons with little evidence At the subcellular level we found sst1 frequently associated with neuronal fibers and terminals, sst2A, sstB, and sst4 with somata and dendrites and sst3 with neuronal cilia. Sites of sst1, sst2A, sst2B and sst4 localization were usually seen to be closely opposed by somatostatin-containing terminals. These observation indicates that the somatostatin signalling system fulfils the anatomical requirements for being functional and modulating a variety of transmission processes.

Reported by

Institut National de la Sante de la Recherche Medicale, INSERM
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