Community Research and Development Information Service - CORDIS

Production of monoclonal antibody to porcine retinol binding protein

Retinol Binding Protein (RBP) is a small molecular weight protein (MW 21,000 Da). It is the exclusive protein for transport of vitamin A (retinol) in the body. Almost all the vitamin A in blood is bound to RBP. RBP is synthesized mainly in the liver by parenchymal hepatocytes (Yamada et al 1987). In the endoplasmic reticulum in the liver RBP picks up one molecule of retinol. The synthesis of RBP and its secretion from hepatocytes is mainly controlled by retinol. RBP in the plasma is bound to another, larger protein, transthyretin (TTR). TTR is a tetrameric protein with a molecular mass of approximately 55,000 Da.

Monoclonal antibodies were prepared against porcine RBP. Development of an ELISA is in progress.

More information on the APP IN PIG PRODUCTIO -project can be found at:

Reported by

Utrecht University
Yalelaan 1
3584 CL Utrecht
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