Community Research and Development Information Service - CORDIS

Pig APP levels on commercial farms

In this work the concentration of the APP (acute phase proteins) Pig-MAP, haptoglobin, CRP and ApoA-I has been determined in pigs from commercial farms located in Segovia, Spain. The aim of the study was to establish a range of concentration of these proteins in normal state, as well as to analyse the potential of these markers to evaluate the general health status of farms.

Serum samples from reproductive sows (Large White x Landrace) having none to five parturitions were collected in 9 commercial farms (5 animals per age and farm, randomly selected). The mean values of Pig-MAP and haptoglobin in the total of sows studied were respectively of 0.81+0.39 and 1.16+0.59mg/ml. There were no differences in the concentration of Pig-MAP or haptoglobin depending on the number of parturitions of the sows.

In the case of the negative APP ApoA-I higher levels (p<0.0001) were found in sows having none parturition (2,45 mg/ml), being the rest of the values similar (1,59mg/ml). The mean values of Pig-MAP and haptoglobin concentration in reproductiveboars (Large White) were respectively 1.26mg/ml and 0.75mg/ml. Thus, a sex effect was found, being the opposite for haptoglobin and Pig-MAP. The mean concentration of the APP studied was not modified during the period of collection of the samples (1 year, at 4 months intervals), and there were no significant differences between the two insemination centres included in the study.

To determine the concentration of APP in the growing finishing period, serum samples were obtained in 6 farms from animals of 28, 60, 90, 120, 150 days age. The concentration of Pig-MAP tended to decrease slightly with time. Mean values for each age ranged from 1.16 to 0.73mg/ml, and from 1.10 to 0.72mg/ml for haptoglobin (no significant differences between ages).

In a second study, the APP levels were compared in two farms of different health status and managing conditions. One of the farms was a high health status farm with excellent performance, free of A. pleuropneumoniae, PRRSv, S. suis and mange, and with low mortality (<2%). Farm B was a low health status farm, with high prevalence of actinobacilosis due to A. pleuropneumoniae, PRSSv and mycoplasmosis due to M. hyopneumoniae, and a mortality >12% during the period of analysis. The concentration of the positive APP in the farm of high health status remained constant during the period of analysis. In the farm of low health status significantly higher levels of the positive APP, and a decrease of ApoA-I were found in animals of 3, 9 and 13 weeks of live.

Results obtained in this study indicate that the determination of APP may become a useful tool when evaluating the general health status of farms. The use of an APP index increased the differences observed between farms.

More information on the APP IN PIG PRODUCTIO -project can be found at:

Related information

Reported by

PigCHAMP Pro Europa S.A.
Ctra S. Rafael 42
40006 Segovia
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