Community Research and Development Information Service - CORDIS

Validation of the newly developed t-Tgase antibody kits by comparing them to the state of the art endomysial antibody test (EMA test) and choice of the best performing one

The aim of the Coeliac-EU Cluster Epidemiology was also to provide new simple serologic diagnostic tests suitable for large population screening programmes. In associated projects the screening tools were further evaluated using the healthy first-degree relatives within multiple case coeliac families as the target. The autoantibody tests were correlated to coeliac disease HLA genetics and an approach to detect IgA deficient individuals was undertaken.

Endomysial or tissue transglutaminase autoantibody positivity was confirmed as a specific and sensitive measure of coeliac disease.

Indeed project allows the development of tools for clinical case finding by screening and population-based screening programmes. These tools, endomysial and tissue transglutaminase autoantibody serum tests accurately detected clinically silent coeliac disease. The antibody tests correlate with coeliac-type HLA DQ2 and DQ8. Based on the project results, the SEM partner, Eurospital, SpA, has launched two new diagnostic kits on the market, measuring tissue transglutaminase antibodies. Laboratory non-dependent validated screening tools are now available for coeliac disease case finding. Health care professionals are able to identify individuals needing life-long exclusion of wheat, rye, and barley in their daily diet.

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