Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Preliminary small animals studies indicating superior properties of new scaffold for short term bone regeneration

New scaffolds for bone regeneration present characteristics have to undergo a series of controls before being "passed". A reliable way of verifying the ability of the scaffolds to allow bone formation and vascularisation is the use of ectopic bone formation assays in a small animal model. Bone formation has been therefore assessed by implanting "in vivo" human Osteoprogenitor Cells (Bone Marrow Stromal Cells) combined to the new bioceramic scaffolds subcutaneously in immunodeficient mice. In this system human bone formation occurs within few weeks. This model system also allows the study of bone scaffolds interaction. Preliminary results have indicated excellent bone formation and in general superior properties of new scaffold for bone regeneration

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