Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Cancer risk predictivity of different types of chromosome damage

Data on the role of the type of chromosomal aberrations (CAs) in cancer predictivity were obtained from Nordic, Italian, and Czech and other NAS cohorts. The findings suggested that both chromatid- and chromosome-type CAs are predictive of cancer risk, although chromosome-type CAs appeared to have a more important influence.

Before the present project, information had been available on the role of CA type only from a small Taiwanese study. The present results are important in directing future research on the connection between CAs and cancer risk. They may suggest that emphasis should be aimed at studying the role of exposure to ionising radiation, a major source of chromosome-type CAs. The data from the Nordic-Italian and Czech studies have been published and presented in various scientific meetings. A manuscript has been prepared on the results of the other NAS cohorts.

Sister chromatid exchanges (SCEs) were not indicative of cancer risk. The alternative use of high frequency SCE cells (HFCs) instead of mean number of SCEs per cell as the variable did not improve the cancer predicitivity of SCE analysis. A full-scale epidemiologic analysis of the cancer risk predictivity of SCEs with the supplemental information collected on technical features of the SCE test was not feasible.

Thus, the results confirmed that the analysis of SCEs does not appear to have use in cancer prediction. The SCE assay can be used, e.g., in specific studies of occupational exposures to genotoxic carcinogens - where variation among culture batches and SCE analysis can be controlled between the exposed subjects and their referents. When data from various studies are combined for cancer risk prediction evaluation, the technical variation in SCE level is very difficult to manage. The classification of subjects in groups with high, medium, and low SCE counts thus becomes highly unreliable. The results on the cancer risk predictivity of SCEs and HFCs in the Italian cohort have been published. A manuscript is being prepared on the feasibility study.

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Reported by

Lund University Hospital
Divison of Occupational and Environmental Medicine and Psychiatric Epidemiology
22185 Lund
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