Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

Cancer risk predictivity of cytogenetic biomarkers in new national cohorts and in a pooled european cohort

Studies on the cancer risk predictivity of chromosomal aberrations (CAs) concerned altogether 10 cohorts from four Nordic countries, Italy, Czech Republic, and 5 other countries who joined the project via NAS extension. The cohorts comprised altogether 21,832 subjects. The studies clearly showed that CA frequency is predictive of cancer. This predictivity was not due to undetected cancer, because it did not depend on the time elapsed from the CA analysis to the cancer detection. Both the Czech and the new NAS cohorts showed an association especially with stomach cancer. In the NAS cohort, a strong association also existed to colorectal cancer. The ongoing analysis of the pooled European cohort will shed more light on this matter. Thus, the results show that a positive chromosome aberration study, e.g., in occupational settings is an indication of increased cancer risk - besides exposure to genotoxic carcinogens. Confirmation of the cancer risk predictivity of chromosome damage can be utilised in development of strategies for cancer risk management and in risk assessment of genotoxic carcinogens by EU, WHO, and national regulatory bodies. The results will be useful for occupational physicians and toxicologists, radiation surveillance professionals, geneticists, and epidemiologists.

The results will form a basis for planning a new collaborative project that should assess, e.g.,
(a) how the cancer risk predictivity of chromosome damage could be taken into account in regulation,
(b) what are the prospects for individual risk assessment, and
(c) what could explain the apparent preferential prediction of stomach cancer and colorectal cancer.

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