Deliverables Enzymes involved in the hypoxic response As outlined in the scientific reports, the family of oxygenases that are central to the activity of TNA are involved in the hypoxic response involving hypoxia inducible factor. The latter has been termed a master switch for blood vessel growth (angiogenesis) and its control is therefore of enormous potential in the treatment of cardiovascular disease and cancer. Work by the Partners in collaboration with others has led to the identification of the 'angiogenesis oxygenases'. A key element in this work was the structural work generated as part of TNA. This work has attracted very widespread attention and has stimulated new lines of research in many other laboratories worldwide. It has led to the creation of a 'spin-out' company, ReOx, focusing the development of new treatments for ischemic disease Enzymes in clavam biosynthesis The work has resulted in the identification of enzymes that catalyse the formation of the beta-lactam ring in the biosynthesis of important antibiotics including the carbapenems and the ß-lactamase inhibitor clavulanic acid. These enzymes, or modified forms thereof, may be useful in the production of medicinally useful beta-lactam antibiotics. Structure of oxygenases involved in cephalosporin biosynthesis The work has resulted in crystal structures for the enzyme (deacetoxycephalosporin-C synthase ) that converts penicillins into the commercially and medicinally important cephalosporin antibiotics. The structures reveal the unusual way in which the enzyme binds its penicillin substrate and show how the active site of the enzyme can be modified to accept other penicillins, specifically those with hydrophobic side chains. The modified forms of deacetoxycephalosporin-C synthase can be used to develop more efficient routes to the cephalosporin antibiotics Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
