Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

New compounds have been sysnthesised and developed. They inhibit the vacuolar H+ ATPase and have been useful in both ESR and fluorescence experiments for determining the approximate site on the prote

A range of chemcial compounds have been synthesised which are able to inhibit the enzyme complex. Some represent quite new approaches to interfering with the mechanism of action of the enzyme. These compounds may have value as leads in the development of therapeutic approaches to osteoporosis and cancer.

Reported by

School of Biochemistry & Microbiology
School of Biochemisty & Microbiology, University of Leeds
LS2 9JT Leeds
United Kingdom
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