Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Handbook of validated models, measurement techniques and testing of measurement techniques and process actuators for crystallization

The applicability of the developed process models, selected measurement techniques and process actuators was tested on, lab, pilot and production scale environments (deliverables 6.1 through 6.4). In general the process model gave a good description of the crystallization process enabling the optimisation, debottlenecking and trouble shouting of processes and the application of model predictive control. The tests of the sensors showed several limitations of the measurement techniques. Especially crystal size distribution measurements in an in-line environment proved difficult. Important issues are the crystal concentration, crystal shape and refractive index and colour of the crystals. The tests on the process actuators showed the importance of the early stages of a crystallization process. Process actuators have a large influence on the product quality in the beginning of the process, whereas process actuators in the last stages of a process have a low sensitivity towards the product quality.

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