Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Database of physical, mechanical, chemical, and biological properties of high strength non-ferromagnetic FeAlCr intermetallic alloys

Industrial pilot scale production by Powder Metallurgy of non-ferromagnetic Fe-Al-Cr alloys was completed. Selected alloys have high yield strength (up to 1300 MPa) and some of them reasonable ductility (up to 9%). All they show a good corrosion resistance in vitro that is similar to that of the current biomaterials.

None of the alloys developed during the project was found to be cytotoxic, even when tested, as fine particles were not causing injury to Saos-2 and J774A.1 cells. The uptake of such particles by cells following phagocytosis, with no induction of cell death, was an additional proof of the lack of toxicity of the alloys, in contrast with other authors who found that small ingested particles are most cytotoxic to cells.

When solid surfaces have been assayed, all the candidate alloys have been shown to have good biocompatibility, often approaching the behaviour of materials well known for their biological acceptance, e.g. alumina. The finding of human osteoblasts adhering, spreading and eventually covering with multilayers the surface of the alloys, is strengthening the result of good compatibility in vitro.

The data base of FeAlCr intermetallic alloys processed by Powder Metallurgy including mechanical, chemical and biological properties would allow the identification of potential applications for the fabrication of surgical implants and medical devices.

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