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The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults

The objective of this study was to investigate the relationship between indices of Zn nutritive status and biochemical markers of bone turnover in older adult European subjects. The baseline data from a multi-centre prospective Zn intervention (ZENITH) study was used from France, Italy and Northern Ireland. In total 387 healthy adults, aged 55-87 y participated in this study. Zn intake was assessed by 4-d recall records. Circulating and urinary biochemical Zn status measures were assessed by atomic absorption spectrophometry.

Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC. Zn intake was positively correlated with serum (r=0.129; P<0.05) and urinary (r=0.143; P<0.05) Zn, but not with erythrocyte Zn. Serum Zn was positively correlated with urinary Zn (r=0.200; P<0.0001). Zn intake was negatively correlated with urinary Pyr and Dpyr (r=-0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum Zn to be negatively correlated with urinary Dpyr (r=-0.211; P=0.080). Erythrocyte Zn was negatively correlated with serum osteocalcin (r=-0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research centre) the only significant association, which remained was between serum osteocalcin and erythrocyte Zn (b=-0.124; P=0.011).

There was some, albeit inconsistent, evidence of a relationship between Zn nutritive status and bone turnover in the older adults participants of the ZENITH study.

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Univ. College Cork
Univ. Cork
4251 Cork
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