Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Effect of zinc supplementation on Zn, Fe and Cu status in middle-aged and older European subjects

Inadequate intakes of micronutrients in elderly negatively affect the nutritional status. Zinc (Zn) is an essential micronutrient in the elderly, especially in relation to its impact on immune function, bone mass, cognitive function and oxidative stress. However, data are lacking on Zn interaction with other trace elements during normal aging. In this study, we evaluate the effect of Zn supplementation on trace elements status in late middle-aged and older free-living subjects. Zn, iron (Fe) and copper (Cu) status in 188 middle-aged subjects from Clermont-Ferrand (Fr) and Coleraine (UK), and in 199 older subjects from Grenoble (Fr) and Roma (It) were assessed after 3 and 6 months supplementation with 15 or 30mg/ Zn/d or placebo. In relation to the Zn RDA for people older than 55y, Zn intakes in most of the middle-aged and older subjects (more than 96%) in the present study were adequate.

The prevalence of biological Zn deficiency in free-living aging European people was low (<5%). 30mg/d of Zn increased significantly serum and urinary Zn in middle-aged and older people, but no effect of Zn supplementation on erythrocyte Zn has been observed in the middle-aged and older groups. Fe and Cu status were not modified by Zn supplementation in the middle-aged and older groups. In conclusion, our findings suggest that in our population of middle age and older subjects, Zn supplementation had no adverse effects on Fe and Cu status.

Reported by

Univ. J Fourier
Labo Stress oxydant
38700 La Tronche