Community Research and Development Information Service - CORDIS



Project ID: ICA4-CT-2000-30032
Funded under: FP5-INCO 2
Country: United Kingdom

generation of rBCG strains lacking immunodominant antigens

Genes encoding the antigens mpb63 and mpb83 were eliminated from BCG Pasteur by allelic exchange to generate BCG-delta strains.

These BCG-delta strains may be useful as alternative BCG vaccine strains.

Vaccination with these strains will generate immunity against tuberculosis but complementary diagnostic tests that target the mpb63 and mpb83 antigens may be used to distinguish BCG vaccination from natural infection with M. bovis or M. tuberculosis.

Reported by

University of Surrey
University of Surrey
GU25XH Guildford
United Kingdom
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