Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Development of a DNA biobank of patients affected by male infertility and testicular cancer, and its corresponding population controls

Neocodex is leading a multicentric project devoted to create a DNA bank from common diseases patients and samples from unrelated healthy controls representative from the Spanish general population. Once GENDISRUPT started, Neocodex began the recruitment of biologic samples from infertile patients and testicular tumours patients. All the samples were collected in anonymised fashion in private or public collaborating clinical entities.

These referral centres are:
- Centro Gutenberg (Málaga).
- Hospital Universitario Virgen del Rocío (Sevilla)
- Hospital General Universitario de Alicante (Alicante)
- Fundació Puigvert (Barcelona)
- Hospital La Paz (Madrid)

All the infertile patients fulfil the following inclusion criteria: primary infertility, absence of any known cause of infertility, absence of radiotherapy or chemotherapy, azoospermia or severe oligozoospermia (sperm counts < 5 million spz/ml), absence of Y chromosome microdeletions according to Simoni et al., (1999).

Written informed consent was obtained from all the patients and controls included in the present project. The Institutional Review Boards of referral centres and Neocodex S.L. approved this protocol. Deoxyribonucleic acid banking and genetic tests included in this study have complied with the international regulations regarding the collection, treatment, storage and use of genetic data (International Bioethics Committee, UNESCO SHS-503/2001/CIB-8/3).

Sample type:
Available number

Germinal DNA from severe oligozoospermic or azoospermic males: 167

DNA from control population: 1000

DNA from testicular cancer patients: 101

Fresh tissues from sterile males (testes): 7

Tissue from males affected of testicular carcinoma: 100.

Verwandte Informationen

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Edificio Estación Monoraíl. Avd. Charles Darwin s/n. Isla de la Cartuja
41092 Sevilla
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