Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

Identification of a genetic association of the KIT, KITLG and PTEN genes with male infertility

We have carried out genetic association studies in order to identify a possible role of the signalling pathway KIT/KITLG in male infertility.

We selected the KIT, KITLG, PIK3R1, AKT1 and PTEN human genes involved in this specific pathway.

The analyses of this genes revealed that the KIT, KITLG and PTEN genes could present genetic susceptibility factors affecting the male reproductive function in humans.

We are currently analysing the joint effects of these genes under a multilocus approach.

Positional cloning strategies for the identification of susceptibility factors within these genes have also been designed.

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Edificio Estación Monoraíl. Avd. Charles Darwin s/n. Isla de la Cartuja
41092 Sevilla