Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Identification of nuclear Apaf-1 as a positive prognostic factor in non-small cell lung carcinoma

Dr. Kroemer's team showed that roughly one quarter of resected stage I non-small cell lung carcinomas (NSCLC), (T1N0M0 or T2N0M0), manifested a marked nuclear localization of Apaf-1 (Apaf-1Nuc), as compared to mostly cytoplasmic localization of Apaf-1 found in the majority of tumors (Apaf-1Cyt). Importantly, the subcellular location of Apaf-1 (but not that of p53 or Hsp70) was found to constitute an accurate prognostic factor for overall survival in non-small cell lung carcinoma.

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Centre Nationale de la Recherche Scientifique (CNRS) UMR8125
Institut Gustave Roussy, 39 rue Camille Desmoulins
94805 Villejuif
France