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Proteomic analysis of Cyp450 isoform expression in lung cancer cells

Cytochrome P450 (Cyp450) enzymes have the capability of playing key metabolic roles in several aspects of cancer as a consequence of their unusually broad substrate specificities. Cyp450 are also important in the metabolism of anticancer therapeutic drugs, enhancing or diminishing the efficacy of the drugs depending on whether the drug or its metabolites are efficacious. In the current project we examined the Cyp450 profile of approximately 25 Cyp family members over a panel of NSCLC and SCLC cell lines. We identified a number of differences between the various lung cancer cell lines and are examining whether they might be the reason why cells are refractive to chemotherapy.

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