Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

Database of automatically-generated cortical width for study subjects

This result is a database of computer-generated mandibular cortical width measurements obtained from dental panoramic radiographs using newly developed software. Volunteer female subjects in the 45 to 70 year age band, recruited from four European centres, underwent a Dental Panoramic Radiographic examination and bone densitometry. Two ASM methods, one entirely automatic and one manually initialised, were used to derive measurements of mandibular cortical width. 661 subjects were examined (mean age 54.8y; sd = 6.19y), with 140 (21.2%) being classified as having osteoporosis.

Using the manually initialized ASM method, Az values for the diagnosis of osteoporosis at any site and at the femoral neck alone were 0.818, (95% CI: 0.786 to 0.847) and 0.839, (95% CI: 0.809-0.866), respectively. Using the automatically initialized ASM method, The Az values for the diagnosis of osteoporosis at any site and at the femoral neck alone were 0.762 (95% CI: 0.728 - 0.794) and 0.809; (95% CI: 0.777 to 0.838), respectively. The difference in Az of the two methods was significant (p<0.001).

Conclusions: ASM-based methods of mandibular cortical width measurement were diagnostically effective in diagnosis of osteoporosis. The manually initialised method, involving a small amount of user interaction, performed best. Further analysis is needed to establish the appropriate diagnostic threshold for clinical use.

Potential applications:
This dataset is available for use in determining the diagnostic validity of cortical thickness in diagnosis of osteoporosis: the principal purpose of the OSTEODENT study. It may however, have applications in another context. We have interest in looking at the prospective value of cortical thickness as a means of assessing 'bone quality' in dental implant planning.

End-users of results:
In the context of osteoporosis, the end-users are: 1. the OSTEODENT consortium, 2. Other future collaborative researchers (subject to mutual agreement of consortium), 3. Industrial collaborators interested in developing the software, 4. Dental practitioners (subject to having the software).

Main benefits:
The innovative aspect of this dataset is in the context of the entire OSTEODENT project. It is part of a robust, comprehensive database of information on a pan-European sample that is larger than any previous set. This dataset may have commercial value in acting as a reference population for subsequent work.

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