Community Research and Development Information Service - CORDIS

Dietary recommendations for preventing or postponing the occurrence of hereditary breast cancer

The cloning of two breast cancer susceptibility genes (BRCA1 and 2), along with the introduction of predictive genetic testing, has allowed for the identification of high-risk women. Options currently available for these women include surveillance programs aimed at early detection, prophylactic bilateral mastectomy, and prophylactic oophorectomy, while non-surgical primary prevention options (e.g. chemopreventive options for interrupting the oestrogen-signalling pathway) are not yet firmly established.

The present C.O.S. study is the first study addressing the interaction of dietary habits with BRCA gene mutations. Results indicate that susceptible women have further options for reducing their breast cancer risk. These are sustainable dietary modification as simple as avoiding the consumption of cow milk and increasing the consumption of cruciferous vegetables, suck as broccoli, cabbage, cauliflower and Brussels sprouts. This is the base for implementing dietary recommendations in family clinics for the prevention of heritable breast cancer.

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Istituto Nazionale Tumori
Via Venezian 1
20133 Milan
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