Community Research and Development Information Service - CORDIS

Development of a continuously perfused fixed-bed bioreactor system

Provisional Results of the development of a continously perfused fixed-bed bio-reactor system, tailored to the specific requirements of bone cells in order to obtain a bone tissue construct in vitro were obtained:

In close connection to WP1 and 2 the shape of the reactor was defined. Based on the modularity and miniaturisation of the system, it is also necessary to develop some peripheric compounds like DO and pH-Probes with small size, fittings and measurement for small flowrates and peristaltic pumps for small volumes.

Due to these reasons meredos has first developed a special reactor concept and the necessary electronics, which can be used for the following applications with the change of only few elements and low expenditures:

The vessel-variety is the prerequisite for successful test series with various scaffolds and culture media and for realisation of an organic unity of all elements such as vessel, sampling system, scaffold holder for different shapes, miniaturized sensors, variable flow rates within the microliter range with new miniaturized peristaltic pumps. Furthermore this concept is new on the market and meredos has applied for patent.

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Meredos GmbH
Alte Dorfstrasse 37
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