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Evaluation of strategies to enhance axonal regeneration in a nerve amputee model

We evaluated nerve regeneration in an experimental nerve amputee model in the rat sciatic nerve. Morphological results show that regeneration occurred into a silicone blind chamber, with a large number of axonal profiles indicative of regenerative sprouting. The number of axonal profiles counted at the distal level was sustained over 9 months follow-up, indicating that regenerated axons are maintained even in absence of distal targets. Reconnection of the distal nerve to foreign targets improved the patter of nerve regeneration, decreasing the number of abnormal sprouts.

Reported by

Grup de Neuroplasticitat i Regeneracio, Dept. Biologia Cel.lular, Fisiologia i Immunologia, Institut de Neurociencies, Edif. M
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