Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Development of a new protocol for the 6-OH oxidation of mono/oligosaccharides and application of the above protocol for an efficient synthesis of hexuronic acid (GlcA and IdoA)-containing disaccharide

A new protocol for the oxidation of the primary hydroxyl of mono or oligosaccharides has been developed. It consists in two steps, oxidation to aldehyde with IBX (a procedure never used before for carbohydrates), followed by further oxidation to carboxyl group. The above protocol has been used for an efficient synthesis of hexuronic acid (GlcA and IdoA)-containing disaccharides. Of these acids, the IdoA is particularly difficult to obtain through classical methods. The compound so obtained has the skeleton of a glycosaminoglycan repeating unit and is an intermediate useful to build glycosaminoglycan fragments in a controlled way.

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THE UNIVERSITY OF MILANO
Via Venezian 21
20133 MILANO
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