Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

VEGFR2 mutants to inhibit angiogenesis

In order to achieve a specific blockade of VEGF-induced tumour angiogenesis and also to maintain vascular permeability, which would be important for combination therapies with cytostatic compounds, partner 3 and 7 mutated VEGFR1 and targeted the tyrosine residues in the intracellular domain of the VEGFR-2. For a detailed and systematic functional analysis of single tyrosine groups in signalling all tyrosine groups were exchanged against phenylalanine in the murine VEGFR-2 and these VEGFR-2 mutants transfected into human endothelial cells (EC) for Western blot analysis.

Publication:
Heidenreich R, Machein M, Nicolaus A, Hilbig A, Wild C, Clauss M, Plate KH, Breier G. Inhibition of solid tumor growth by gene transfer of VEGF receptor-1 mutants. Int J Cancer 2004;111:348-57. VEGFR2 data so far unpublished.

Reported by

TECHNICAL UNIVERSITY DRESDEN
Fetscherstrasse 74
01307 Dresden
Germany
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