Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

Wood dust-induced inflammation response in rat primary lung macrophages and lung cells in vitro

Respiratory symptoms, impaired lung function, and asthma have been reported in workers exposed to wood dust in a number of epidemiological studies. The underlying pathomechanisms, however, are not well understood. By the secretion of various cytokines, alveolar macrophages and type II lung epithelial cells are involved in the initiation and modulation of the inflammatory reaction in the lung.

The in vitro data from experiments carried out using primary rat alveolar macrophages and lung epithelial cells indicate that:
- Dusts from various hardwood and softwood species as well as dust from MDF are able to induce the release of proinflammatory mediators in primary alveolar macrophages by a mechanism that is, at least in part, mediated by ROS and

- The release of proinflammatory mediators from wood dust-exposed macrophages may be important in stimulating cytokine release from lung epithelial cells, thus amplifying the inflammatory response.

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