Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Molecular epidemiology study on sino-nasal cancer: KRAS mutations

Epidemiological studies show that the highest risks of sino-nasal cancer in association with occupational exposure have been observed for hardrwood dusts and adenocarcinoma histology. According to previous studies, KRAS oncogene mutations have been found to occur in adenocarcinoma of the nose and paranasal sinuses. In the present investigation, the SNC tumour collection from Denmark, Finland and France was analysed for KRAS mutations.

The series of tumours under investigation (~300 tumours) included a representative collection of confirmed adenocarcinomas. However, the frequency of KRAS mutations detected in the tumours remained low. The KRAS mutation analysis is part of the overall molecular epidemiology study on SNC for which the data analysis will be performed after completion of exposure assessment for the cases. In summary, our current molecular analysis indicates, unlike earlier data, that mutations in the tumour suppressor gene p53, rather than those of the KRAS gene, are common in SNC.

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